Interleukins in inflammation

The interleukins in acquired disease.

Interleukins adapt to parasites

TLR choreography Pathogen-sensing Toll-like receptors (TLRs) must be deployed accurately. Here, Fukui et al. show how finely tuned these receptors are. Tweaking a single amino acid in a TLR-trafficking molecule determined whether the signal was green or red for nucleic acid–sensing TLRs (page 1339). TLR7 and TLR9 recognize viral nucleic acids—RNA and DNA, respectively—in endolysosomes. By seque...

Measurement of interleukins in vitreous infusion fluid.

Measurements of interleukin (IL)-6 and -10 concentrations in the vitreous can be used to differentiate intraocular lymphoma (IOL) from uveitis. This is the first study reporting the IL-6 and -10 concentrations in the undiluted vitreous fluid and vitreous infusion fluid, which were simultaneously examined in the patients. A total of 2 females presented with intraocular inflammation, and underwen...

Salivary and crevicular fluid interleukins in gingivitis

INTRODUCTION Gingivitis is a frequent inflammatory process of the gum tissue that is mainly caused by the accumulation of plaque. The immune response against inflammatory processes is regulated in part by cytokines. AIMS Given that a continuous inflammation exists in gingivitis, it would be logical to assume that the interleukins will be altered locally in those patients. Therefore, the aim o...

Interleukins in glioblastoma pathophysiology: implications for therapy.

Despite considerable amount of research, the poor prognosis of patients diagnosed with glioblastoma multiforme (GBM) critically needs new drug development to improve clinical outcomes. The development of an inflammatory microenvironment has long been considered important in the initiation and progression of glioblastoma; however, the success of developing therapeutic approaches to target inflam...